Research & What You Get…


1. “What you Get” with the VaginaLab™ Program…

Ten years ago, there were zero drugs approved by the FDA for the treatment of female sexual dysfunction. Thankfully, in the decade since Dr. Charles Runels designed the O-Shot® procedure, a noticeable number of new therapies have appeared.

In an effort to combine the best of therapies for a noticeable result, the VaginaLab™ package strategically brings a woman to her best sexual health, pleasure, and connection. There are no magic bullets in medicine–the body is so complicated that almost always best health requires a thoughtful, informed combination of therapies that consider the whole system and how it works together.

Though there are no magic formulas, there’s a certain basic combination of ideas that can help almost everyone. For example, almost everyone will see an improvement in thought, emotions, cardiovascular health, and digestion, and sexual function if they walk or jog daily. But, walking alone will not make all sexual problems go away.

In thinking about what almost every woman needs to do to see her best sexual health, Dr. Runels came up with the following ultimate-best combination of therapies:

  1. Daily walking. It’s difficult to be healthy if you’re sedentary. Ideally, you walk up to 21-25 miles of comfortable walking per week.
  2. Good sleep. Most require 7-8 hours. Some of us function on 5 with an afternoon nap. But, whatever your quota, you need that and you need it with a regular go-to-bed time and a regular wake-up time most of the time.
  3. Hormonal optimization. This can be tricky. For example, it’s a known side effect of birth control pills that they lower testosterone in women–causing many women to experience a multitude of problems including weight gain, loss of sex drive, migraines, and even chronic pain with sex that does not go away when you stop the birth control pills. Some women cannot use any hormonal replacement but most women do benefit from a careful measurement and adjustment of hormones based on symptoms and previous history.
  4. O-Shot® procedure. Improving the health (blood flow, nerve conduction, and collagen structure) in the vagina, peri-urethral, and clitoral area is not everything but it sure does help many women: this improvement in tissue health is exactly what the O-Shot® procedure can do in most women–this one procedure can change lives.
  5. Emsella treatments (though first brought to market for urinary incontinence, it does wonderful things for sex). No one seems to doubt the usefulness of Kegel exercises in both men and women; so, it’s not surprising that many find the amazing benefits from doing 15,000 Kegel contractions in 21 minutes with more strength than can be done on your own. A series of sessions back to back followed by a maintenance plan can be life-changing. Nothing I know of can strengthen the G-Spot Support Muscles (GSSM) the same way.
  6. A strong program of appropriate supplements: a probiotic, a libido enhancer, vitamin E, Vitamin C, and a good B-Complex.
  7. Sex education/counseling for the woman and her lover. Most people don’t know what they don’t know. A combination of book education and in-person counseling goes a long way.
  8. A good arousal oil. Yes, we know good lubrication happens with good sexual health; but a little extra lubrication with the proper ingredients can create a real improvement in response for both partners.
  9. Thoughtful consideration of various classes of vibrators/self stimulators. These aids can both help with discovery and response.
  10. Prescription medications designed for sex like Vyleesi and knowledge about how to best integrate them into your love-making.
  11. Various laser and radio-frequency devices (like the Diva and the Thermi-Va) when needed.
  12. And of course, the right person in your bed (which can mean, just falling in love with yourself)

2. Some of the Research

Kato, Mayumi Kobayashi, Satoru Muro, Tomoyasu Kato, Naoyuki Miyasaka, and Keiichi Akita. “Spatial Distribution of Smooth Muscle Tissue in the Female Pelvic Floor and Surrounding the Urethra and Vagina.” Anatomical Science International 95, no. 4 (September 2020): 516–22.
Tsonis, O., F. Gkrozou, E. Harrison, K. Stefanidis, N. Vrachnis, and M. Paschopoulos. “Female Genital Tract Microbiota Affecting the Risk of Preterm Birth: What Do We Know so Far? A Review.” European Journal of Obstetrics & Gynecology and Reproductive Biology 0, no. 0 (December 2019).
Faubion, Stephanie S, Lynne T Shuster, and Adil E Bharucha. “Recognition and Management of Nonrelaxing Pelvic Floor Dysfunction.” Mayo Clinic Proceedings 87, no. 2 (February 2012): 187–93.
Agar, N. S., and T. Stephens. “Reduced Glutathione–a Comparative Study of Erythrocytes from Various Species of Marsupials in Australia.” Comparative Biochemistry and Physiology. A, Comparative Physiology 52, no. 4 (December 1, 1975): 605–6.
Handy, Ariel B., Amelia M. Stanton, and Cindy M. Meston. “Understanding Women’s Subjective Sexual Arousal Within the Laboratory: Definition, Measurement, and Manipulation.” Sexual Medicine Reviews 6, no. 2 (2018): 201–16.
Hersant, Barbara, Mounia SidAhmed-Mezi, Yazid Belkacemi, Franklin Darmon, Sylvie Bastuji-Garin, Gabrielle Werkoff, Romain Bosc, et al. “Efficacy of Injecting Platelet Concentrate Combined with Hyaluronic Acid for the Treatment of Vulvovaginal Atrophy in Postmenopausal Women with History of Breast Cancer.” Menopause 25, no. 10 (2018): 1.
Jb, Neto. “O-Shot: Platelets Rich Plasma in Intimate Female Treatment,” 2017, 4.
Jhang, Jia-Fong, Shu-Yu Wu, Teng-Yi Lin, and Hann-Chorng Kuo. “Repeated Intravesical Injections of Platelet-Rich Plasma Are Effective in the Treatment of Interstitial Cystitis: A Case Control Pilot Study.” LUTS: Lower Urinary Tract Symptoms 11, no. 2 (2019): O42–47.
———. “Repeated Intravesical Injections of Platelet-Rich Plasma Are Effective in the Treatment of Interstitial Cystitis: A Case Control Pilot Study.” LUTS: Lower Urinary Tract Symptoms 11, no. 2 (2019): O42–47.
Long, Cheng-Yu. “A Pilot Study: Effectiveness of Local Injection of Autologous Platelet-Rich Plasma in Treating Women with Stress Urinary Incontinence.” Scientific Reports, 2021, 9.
Malabarey, Ola, and Jens-Erik Walter. “Collagenoma and Voiding Dysfunction as Complications of Periurethral Bulking.” International Urogynecology Journal 26, no. 7 (July 2015): 1077–78.
Matz, Ethan L, Amy M Pearlman, and Ryan P Terlecki. “Safety and Feasibility of Platelet Rich Fibrin Matrix Injections for Treatment of Common Urologic Conditions.” Investigative and Clinical Urology 59, no. 1 (January 2018): 61–65.
Merhi, Zaher, Serin Seckin, and Marco Mouanness. “REPRODUCTIVE ENDOCRINOLOGY: CASE STUDY Intraovarian PRP Injection Improved Hot Flashes in a Woman With Very Low Ovarian Reserve.” Accessed July 7, 2021.
Nikolopoulos, Kostis I., Vasilios Pergialiotis, Despina Perrea, and Stergios K. Doumouchtsis. “Restoration of the Pubourethral Ligament with Platelet Rich Plasma for the Treatment of Stress Urinary Incontinence.” Medical Hypotheses 90 (May 1, 2016): 29–31.
Prodromidou, Anastasia, Dimitrios Zacharakis, and Stavros Athanasiou. “The Emerging Role on the Use of Platelet-Rich Plasma Products in the Management of Urogynaecological Disorders,” 2021.
Runels, Charles. “A Pilot Study of the Effect of Localized Injections of Autologous Platelet Rich Plasma (PRP) for the Treatment of Female Sexual Dysfunction.” Journal of Women’s Health Care 03, no. 04 (2014).
Sanoulis, Vasileios, Nikolaos Nikolettos, and Nikolaos Vlahos. “The Use of Platelet-Rich Plasma in the Gynaecological Clinical Setting. A Review.” 18, no. 3 (2019): 11.
Share, J. B. “Review of Drug Treatment for Down’s Syndrome Persons.” American Journal of Mental Deficiency 80, no. 4 (January 1976): 388–93.
Sills, Eric Scott, Xiang Li, Natalie S Rickers, Samuel H Wood, and Gianpiero D Palermo. “Metabolic and Neurobehavioral Response Following Intraovarian Administration of Autologous Activated Platelet Rich Plasma: First Qualitative Data.” Neuro Endocrinology Letters 39, no. 6 (January 2019): 427–33.
Zheng, Zhifang. “Materials Selection for the Injection into Vaginal Wall for Treatment of Vaginal Atrophy,” 2021, 11.
Samuels, Julene B., Andrea Pezzella, Joseph Berenholz, and Red Alinsod. “Safety and Efficacy of a Non‐Invasive High‐Intensity Focused Electromagnetic Field (HIFEM) Device for Treatment of Urinary Incontinence and Enhancement of Quality of Life.” Lasers in Surgery and Medicine 51, no. 9 (November 2019): 760–66.
Silantyeva, Elena, Dragana Zarkovic, Evgeniia Astafeva, Ramina Soldatskaia, Mekan Orazov, Marina Belkovskaya, Mark Kurtser, and Academician of the Russian Academy of Sciences. “A Comparative Study on the Effects of High-Intensity Focused Electromagnetic Technology and Electrostimulation for the Treatment of Pelvic Floor Muscles and Urinary Incontinence in Parous Women: Analysis of Posttreatment Data.” Female Pelvic Medicine & Reconstructive Surgery 27, no. 4 (April 2021): 269–73.
Mardinoglu, A., and J. Nielsen. “Systems Medicine and Metabolic Modelling.” Journal of Internal Medicine 271, no. 2 (February 1, 2012): 142–54.
Sayin, Umit. “Doors of Female Orgasmic Consciousness: New Theories on the Peak Experience and Mechanisms of Female Orgasm and Expanded Sexual Response.” NeuroQuantology 10, no. 4 (November 29, 2012).
Stromberg, Joseph. “This Is What Your Brain Looks like during an Orgasm.” Vox, April 1, 2015.
“Systems Medicine: A New Approach to Clinical Practice | Elsevier Enhanced Reader.” Accessed August 30, 2021.
Bernuzzi, Gino, Federica Petraglia, Martina Francesca Pedrini, Massimo De Filippo, Francesco Pogliacomi, Michele Arcangelo Verdano, and Cosimo Costantino. “Use of Platelet-Rich Plasma in the Care of Sports Injuries: Our Experience with Ultrasound-Guided Injection.” Blood Transfusion 12, no. Suppl 1 (January 2014): s229–34.
Bubnov, Rostyslav, Viacheslav Yevseenko, and Igor Semeniv. “Ultrasound Guided Injections of Platelets Rich Plasma for Muscle Injury in Professional Athletes. Comparative Study.,” n.d., 5.
Middleton, Kellie K, Victor Barro, Bart Muller, Satosha Terada, and Freddie H Fu. “Evaluation of the Effects of Platelet-Rich Plasma (PRP) Therapy Involved in the Healing of Sports-Related Soft Tissue Injuries.” The Iowa Orthopaedic Journal 32 (2012): 150–63.
Alves, Rubina, and Ramon Grimalt. “A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification.” Skin Appendage Disorders 4, no. 1 (January 2018): 18–24.
Number 5, STL Volume 24. “Platelet-Rich Plasma (PRP): Current Applications in Dermatology.” Accessed August 26, 2021.
Sánchez, Mikel, Eduardo Anitua, Diego Delgado, Peio Sanchez, Roberto Prado, Gorka Orive, and Sabino Padilla. “Platelet-Rich Plasma, a Source of Autologous Growth Factors and Biomimetic Scaffold for Peripheral Nerve Regeneration.” Expert Opinion on Biological Therapy 17, no. 2 (February 1, 2017): 197–212.
Chicharro-Alcántara, Deborah, Mónica Rubio-Zaragoza, Elena Damiá-Giménez, José M. Carrillo-Poveda, Belén Cuervo-Serrato, Pau Peláez-Gorrea, and Joaquín J. Sopena-Juncosa. “Platelet Rich Plasma: New Insights for Cutaneous Wound Healing Management.” Journal of Functional Biomaterials 9, no. 1 (January 18, 2018): 10.
“Platelet-Rich Plasma as an Additional Therapeutic Option for Infected Wounds with Multi-Drug Resistant Bacteria: In Vitro Antibacterial Activity Study – Art%3A10.1007%2Fs00068-018-0957-0,” n.d.
Spanò, Raffaele, Anita Muraglia, Maria R. Todeschi, Marta Nardini, Paolo Strada, Ranieri Cancedda, and Maddalena Mastrogiacomo. “Platelet-Rich Plasma-Based Bioactive Membrane as a New Advanced Wound Care Tool.” Journal of Tissue Engineering and Regenerative Medicine 12, no. 1 (2018): e82–96.
Chung, Eric. “Regenerative Technology to Restore and Preserve Erectile Function in Men Following Prostate Cancer Treatment: Evidence for Penile Rehabilitation in the Context of Prostate Cancer Survivorship.” Therapeutic Advances in Urology 13 (January 1, 2021): 17562872211026420.
Foy, Christian A., William F. Micheo, and Damien P. Kuffler. “Functional Recovery Following Repair of Long Nerve Gaps in Senior Patient 2.6 Years Posttrauma.” Plastic and Reconstructive Surgery. Global Open 9, no. 9 (September 2021): e3831.
Kuffler, Damien P. “Platelet-Rich Plasma and the Elimination of Neuropathic Pain.” Molecular Neurobiology 48, no. 2 (October 2013): 315–32.
Sánchez, Mikel, Eduardo Anitua, Diego Delgado, Peio Sanchez, Roberto Prado, Gorka Orive, and Sabino Padilla. “Platelet-Rich Plasma, a Source of Autologous Growth Factors and Biomimetic Scaffold for Peripheral Nerve Regeneration.” Expert Opinion on Biological Therapy 17, no. 2 (February 1, 2017): 197–212.
Wu, Yi-No, Chun-Hou Liao, Kuo-Chiang Chen, and Han-Sun Chiang. “Dual Effect of Chitosan Activated Platelet Rich Plasma (CPRP) Improved Erectile Function after Cavernous Nerve Injury.” Journal of the Formosan Medical Association, March 27, 2021.

VaginaLab™ Protocol:

Day 0
A detailed discussion with the physician about hormone levels, overall health and health practices, and relationships. O-Shot® procedure. Emsella Treatment. Begin supplements and walking program.

Days 1-21
6 Emsella treatments. Couple practices sexual exercises as per sex therapist/educator. Hormones are adjusted. Medications are adjusted as needed. Medications for improving sex may be started.

Month 2
Another O-Shot

Months 3-6
Two Emsella treatments per month

The doctor is seen as needed but at least on Day 0 and with the second O-Shot® and on the phone 3 times over the first 2 months.

Cost for the above treatments at full price:
O-Shot® procedure x 2 ($1,500 each)…… $3,000
Emsella treatments x 14 (6 in first 3 weeks then 2 per month for months 4, 5, and 6 @ $300 each)………………………………$4,200
Arousal Oil, Probiotic, & Libido Pills (1 month supply x 6)….. $660
Total Cost…..$7,860

Bought as a package, discounted $1,000 for a total price of $6,487.

Call or text if questions if this plan may work for you:

You can also schedule the first O-Shot® & Emsella Treatment, and begin the VaginaLab™ protocol. Call 210 483-6255 to discuss if the treatment is right for you and to schedule your first appointment.


190829 snappr office angele 22
Alexandra Runnels,MD

P.S. You can also book an O-Shot® alone,

P.P.S. You can also book a series of Six Emsella Treatments (either for stress urinary incontinence & or G-Spot Support Muscle[GSSM] improvement),,by clicking here<–


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